There is so much personal value placed on items that you have touched. Especially those that come from your heart and soul. Though if those same items are beginning to weigh on you, then it is time for a change.
You may reduce in stages taking a large amount and letting go of 1 for every 3, then repeat again 1 for 2.
Without knowing many factors in your question, I would say pick up two pieces. One in each hand. Which one feels better? Say goodbye to the other. It is tough. Though you will feel a huge weight lifted from you.
I believe you can do this.